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Search Results for " atp synthesis "

27

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T82944	ATP Synthesis-IN-2
	ATP Synthesis-IN-2 (Compound 5) 是一种有效的ATP合成活性抑制剂，对Pseudomonas aeruginosa (PA) 表现出抗菌活性，其IC50值为0.7 μg/mL。
T39785L	TH5427	NUDIX hydrolase	Metabolism
	TH5427 在 NUDT5 活性和 ADP-核糖代谢中有研究的价值。它阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5是乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
T82945	ATP Synthesis-IN-1
	ATP Synthesis-IN-1（Compound 4）为喹啉衍生物，有效抑制PA ATP合成，IC50为11.1μg/mL。本化合物亦展示抗菌特性，适用于研究耐药PA感染。
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T65979	Adenosine 5'-monophosphate disodium salt Adenosine Phosphate Disodium,5‘-AMP-NA2	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Adenosine 5'-monophosphate disodium salt (Adenosine Phosphate Disodium) 是一种参与 ATP 代谢的嘌呤核苷酸，用于研究 ATP 对细胞和生物体的影响。Adenosine 5'-monophosphate disodium salt 已被证明具有多种生化和生理作用,它可以促进细胞代谢、基因表达和蛋白质合成。
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T8785	HALOFUGINONE LACTATE	DNA/RNA Synthesis; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells
	HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物，它是一种天然的含有喹唑啉酮的化合物，存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶，Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂，通过抑制 TGF-β 活性来减轻骨关节炎 (OA)
T19661	8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂，可能用于治疗慢性淋巴细胞白血病。它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性；在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。
T6501	Fludarabine Phosphate NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶，从而中断 DNA 合成并抑制肿瘤细胞生长。
T11243	Ethyl tosylcarbamate	Others	Others
	Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877).
T61649	ATP synthase inhibitor 2
	ATP synthase inhibitor2 是一个铜绿假单胞菌 (PA)ATP synthase 抑制剂 (IC50=10 μg/mL)，在 128 μg/mL 时可完全抑制铜绿假单胞菌 (PA) 的 ATP 合成活性。
T40522	3'-Deoxy-3'-amino-ATP
	3'-Deoxy-3'-amino-ATP, an ATP analogue, is a highly effective and competitive inhibitor of ATP, exhibiting a K i value of 2.3 μM. Its application includes the synthesis of 3′-Amino-3′-deoxy transfer RNA by integrating it into the 3' terminus of tRNA-C-C.
T74087	2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium
	2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium 是 ATP 类似物，对 poly(AU) 合成有显著的抑制效果。
T79004	ATP synthase inhibitor 2 TFA
	ATP synthase inhibitor2 (Compound 22) TFA 为针对铜绿假单胞菌 (PA) ATP synthase 的抑制剂，具IC50值为10 μg/mL，在浓度达到128 μg/mL 时能够全面阻断铜绿假单胞菌 (PA) ATP的合成活性。
T33737	NSC 109555 NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS
	NSC 109555 是一种选择性、可逆、ATP竞争性的Chk2抑制剂（IC50=0.2μM），对包括Chk1在内的一系列其他激酶没有影响（IC50>10μM）。抑制组蛋白H1磷酸化（IC50=0.24μM）并减弱线粒体ATP合成。在许多体内白血病中表现出抗增殖活性。
T35454	γ-Glu-Cys (ammonium salt)
	γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.2
T83786	8-Chloroadenosine-5'-triphosphate sodium 8-chloro ATP
	8-Chloroadenosine-5’-triphosphate（8-chloro ATP）是抗癌剂8-chloro cAMP的活性代谢物，也是核苷酸腺苷5’-三磷酸（ATP）的衍生物。它通过8-chloro cAMP、8-chloroadenosine以及一磷酸和二磷酸中间体形成。应用8-chloro cAMP或8-chloroadenosine后，8-chloro ATP可累积长达12小时，与细胞生长抑制、内源性ATP水平下降以及患者源多发性骨髓瘤细胞中RNA合成减少（但DNA合成不受影响）相关。在1.5至8 mM浓度范围内，它抑制topoisomerase II-α依赖的超螺旋pUC19 DNA放松，同时在1 mM时减少了K562人髓性白血病细胞中topoisomerase II-α催化的ATP水解50%。
T39785	TH5427 hydrochloride
	TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
T70957	NMac1
	NMac1is a small molecule phenylbutenoid dimer that has novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells. NMac1 causes significant activation of AMPK by decreasing ATP synthesis, lowers mitochondrial membrane potential (MMP, ΔΨm), and inhibits oxygen consumption rate (OCR) under glucose starvation. These effects of NMac1 are provoked by a consequence of OXPHOS complex I inhibition.
T74088	Fludarabine triphosphate trisodium
	Fludarabine triphosphate (F-ara-ATP) trisodium 是Fludarabine 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA 引发酶 (DNA primase) 抑制剂，其IC50为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA 聚合酶，导致细胞凋亡 (apoptosis)。
T35652	2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
	2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.
T73980	Thymidine 5′-diphosphate
	Thymidine 5′-diphosphate (dTDP) 是合成嘧啶的关键产物，通过胸苷酸激酶 (TMPK) 对 5'-单磷酸胸苷 (dTMP) 进行磷酸化反应生成，此过程需 ATP 与 Mg2+。进一步，dTDP 可被 TMPK 催化转化为胸苷 5'-三磷酸 (dTTP)。通过测量 dTDP 水平，可以评估 TMPK 活性。
T83815	6-Chloropurine riboside-5'-triphosphate sodium 6-chloro PuTP
	6-Chloropurine riboside-5'-triphosphate是一种RNA三磷酸酶mRNA-帽化酶β亚单位(Cet1; IC50 = 2 µM，针对S. cerevisiae酶的GTPase活性)的抑制剂，同时也是6-chloropurine riboside的磷酸化形式。此外，它还能激活E. coli天冬氨酸氨甲酰转移酶(EC50 = 0.76 mM)。6-Chloropurine riboside-5'-triphosphate已在合成具有抗癌活性的细胞因子以及一种光点击形式的ATP中得到应用。
T37248	Pantothenate Kinase Inhibitor
	Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A .1It binds to the ATP-PanK3 complex with an apparent binding constant of 300 nM and exhibits mixed-type inhibition with respect to ATP and pantothenate. PANKi inhibits CoA biosynthesis in C3A cells (IC50= 0.9 μM) with no effect on cell viability when used at concentrations up to...
T83807	Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium Rp-ATP-α-S
	Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。
T35655	2,6-Dichloropurine-9-β-D-riboside
	2,6-Dichloropurine-9-β-D-riboside is a building block.1,2It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins. 1.Wower, J., Hixson, S.S., Sylvers, L.A., et al.Synthesis of 2,6-diazido-9-(β-D-ribofuranosyl)purine 3',5'-bisphosphate: Incorporation into transfer RNA and photochemical labeling of Escherichia coli ribosomesBioconjug. Chem.5(2)158-161(1994) 2.Seiter, M.S., Bauer, M.P., Bogel, P.D., et al.Synthesis of novel spin-labeled photoaffinity deriva...
T35533	6-Hydroxypyridin-3-ylboronic Acid
	6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2 1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.1...

化合物

ATP Synthesis-IN-2

Cat.No: T82944

Cat.No: T39785L

Target: NUDIX hydrolase

ATP Synthesis-IN-1

Cat.No: T82945

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Adenosine 5'-monophosphate disodium salt

Cat.No: T65979

Synonym: Adenosine Phosphate Disodium,5‘-AMP-NA2

Target: Nucleoside Antimetabolite/Analog

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

HALOFUGINONE LACTATE

Cat.No: T8785

Target: DNA/RNA Synthesis, TGF-beta/Smad

8-Chloroadenosine

Cat.No: T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷

Target: AMPK

Fludarabine Phosphate

Cat.No: T6501

Synonym: NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Ethyl tosylcarbamate

Cat.No: T11243

Target: Others

ATP synthase inhibitor 2

Cat.No: T61649

3'-Deoxy-3'-amino-ATP

Cat.No: T40522

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium

Cat.No: T74087

ATP synthase inhibitor 2 TFA

Cat.No: T79004

Cat.No: T33737

Synonym: NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS

γ-Glu-Cys (ammonium salt)

Cat.No: T35454

8-Chloroadenosine-5'-triphosphate sodium

Cat.No: T83786

Synonym: 8-chloro ATP

TH5427 hydrochloride

Cat.No: T39785

Cat.No: T70957

Fludarabine triphosphate trisodium

Cat.No: T74088

2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

Cat.No: T35652

Thymidine 5′-diphosphate

Cat.No: T73980

6-Chloropurine riboside-5'-triphosphate sodium

Cat.No: T83815

Synonym: 6-chloro PuTP

Pantothenate Kinase Inhibitor

Cat.No: T37248

Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83807

Synonym: Rp-ATP-α-S

2,6-Dichloropurine-9-β-D-riboside

Cat.No: T35655

6-Hydroxypyridin-3-ylboronic Acid

Cat.No: T35533

Cat. No.	Product Name	Target	Signaling Pathways
T12045	(-)-Hydroxycitric acid lactone 藤黄内酯,Garcinia lactone	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂，能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药，是一种广受欢迎的减肥食品补充剂。
T40426	Cytidine 5'-diphosphate trisodium salt CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐	Others	Others
	Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。
T0064	Adenine Vitamin B4,腺嘌呤,6-Aminopurine	DNA/RNA Synthesis; Endogenous Metabolite; AChR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Neuroscience
	Adenine (6-Aminopurine) 是一种嘌呤衍生物，是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用，作为 DNA 和 RNA 的化学成分。
T11590	(-)-Hydroxycitric acid Garcinia acid,(-)-羟基柠檬酸	ATP Citrate Lyase	Metabolism
	(-)-Hydroxycitric acid (Garcinia acid) 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂，能够抑制脂肪酸的合成，减少脂肪生成，控制食物摄入，从而减轻体重。
T4826	L-Histidine monohydrochloride monohydrat	Others; Endogenous Metabolite	Metabolism; Others
	L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一，即蛋白质的组成部分。
TN6565	Maculosidin
	Maculosidine affect the PS I electron acceptors on leaf discs, it can inhibit ATP synthesis, basal, phosphorylating and uncoupled electron transport acting as Hill reaction inhibitors on spinach chloroplasts.
T81158	Siderin
	Siderin作为一种Photosystem II抑制剂，有效地阻断了离体菠菜光合过程中ATP的合成及叶绿体电子传递，因此被用于植物光合作用的研究。
TN1751	Hydroxycitric acid	ERK; p38 MAPK; Fatty Acid Synthase	MAPK; Metabolism
	(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.
T40483	8-Aminoadenosine 8-NH2-Ado,8-氨基腺苷
	8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. Furthermore, it effectively obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity further highlights its therapeutic potential.

天然产物

(-)-Hydroxycitric acid lactone

Cat.No: T12045

Synonym: 藤黄内酯,Garcinia lactone

Target: ATP Citrate Lyase

Cytidine 5'-diphosphate trisodium salt

Cat.No: T40426

Synonym: CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐

Target: Others

Cat.No: T0064

Synonym: Vitamin B4,腺嘌呤,6-Aminopurine

Target: DNA/RNA Synthesis, Endogenous Metabolite, AChR

(-)-Hydroxycitric acid

Cat.No: T11590

Synonym: Garcinia acid,(-)-羟基柠檬酸

Target: ATP Citrate Lyase

L-Histidine monohydrochloride monohydrat

Cat.No: T4826

Target: Others, Endogenous Metabolite

Cat.No: TN6565

Cat.No: T81158

Hydroxycitric acid

Cat.No: TN1751

Target: ERK, p38 MAPK, Fatty Acid Synthase

8-Aminoadenosine

Cat.No: T40483

Synonym: 8-NH2-Ado,8-氨基腺苷

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